The need for PDHK (pyruvate dehydrogenase kinase) 2 and 4 in regulation from the PDH complex (pyruvate dehydrogenase complex) was assessed in single- and double-knockout mice. double-knockout mice had been even more delicate than single-knockout and wild-type mice to long-term fasting, succumbing to hypoglycaemia, hypothermia and ketoacidosis. Steady isotope flux evaluation indicated that hypoglycaemia was… Continue reading The need for PDHK (pyruvate dehydrogenase kinase) 2 and 4 in
Category: Other Transcription Factors
Melanopsin is the photopigment of mammalian intrinsically photosensitive retinal ganglion cells,
Melanopsin is the photopigment of mammalian intrinsically photosensitive retinal ganglion cells, where it contributes to light entrainment of circadian rhythms, and to the pupillary light response. Tissue Preparation C57Bl/6 mice (The Jackson Laboratories, Bar Harbor, ME) were used as the wild-type strain. Melanopsin knockout mice (and < 0.05, repeated measures one-way ANOVA, Bonferroni-corrected), of 65%… Continue reading Melanopsin is the photopigment of mammalian intrinsically photosensitive retinal ganglion cells,