Objective To research the mechanisms by which chronic tobacco smoking promotes intervertebral disc degeneration (IDD) and vertebral degeneration in mice. of untreated mice, respectively. Exposure to tobacco smoke dramatically elevated metalloproteinase-mediated proteolysis of disk aggrecan within its interglobular domains (IGD). Cellular senescence was raised two folds in discs of smoke-exposed mice. Smoke cigarettes publicity elevated… Continue reading Objective To research the mechanisms by which chronic tobacco smoking promotes