The immunodeficiency, centromere instability and facial anomalies (ICF) syndrome is associated to mutations from the DNA methyl-transferase DNMT3B, producing a reduced amount of enzyme activity. inactive heterochromatic locations, satellite transposons and repeats. Interestingly, transcriptional energetic loci and ribosomal RNA repeats escaped global hypomethylation. Despite a genome-wide lack of DNA methylation the epigenetic landscaping and essential… Continue reading The immunodeficiency, centromere instability and facial anomalies (ICF) syndrome is associated